Peter Thall, PhD

Bayesian Statistics in Clinical Trials

 In this seminar, Dr. Thall provides an introduction to Bayesian statistics.

0:00	Introduction
2:20	Elements of Bayesian Statistics
4:35	Beta Distributions
5:40	Simple Example
10:17	Estimating Probabilities of Rare Events
11:19	Simple Example, continued
14:38	Example: Kaplan Meier Estimates of PFS Time Distribution for Each Dose from a Phase I-II Trial of Targeted Agent in Advanced Renal Cancer
18:15	Quantifying Strength of Evidence
28:28	p-values
31:50	Looking at Efficacy and Toxicity- A Simple Example
34:49	Utility Based Clinical Trial Design
37:47	Example: A Radiation Dose-Finding Trial in Pediatric Brain Tumors
42:42	Example: Randomized Subgroup-Specific Comparison of NuPrehab vs Standard of Care Effects on Post-op Morbidity after Esophageal Resection
47:47	Example: PK-Guided vs. Fixed IV Busulfan Dose in Allogeneic Stem Cell Transplantation
52:26	Example: Randomized Pilot Study of T-reg Cell Therapy for ARDS in Intubated COVID-19 Patients